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KMID : 1038620150330030188
Radiation Oncology Journal
2015 Volume.33 No. 3 p.188 ~ p.197
Patterns of care for patients with nasopharyngeal carcinoma (KROG 11-06) in South Korea
Sung Soo-Yoon

Kang Min-Kyu
Kay Chul-Seung
Keum Ki-Chang
Kim Sung-Hwan
Kim Yeon-Sil
Kim Won-Taek
Kim Ji-Yoon
Kim Jin-Hee
Moon Sung-Ho
Ahn Yong-Chan
Oh Young-Taek
Wu Hong-Gyun
Lee Chang-Geol
Chung Woong-Ki
Cho Kwan-Ho
Cho Moon-June
Choi Jin-Hwa
Abstract
Purpose: To investigate the patterns of care for patients with nasopharyngeal carcinoma (NPC) in South Korea.

Materials and Methods: A multi-institutional retrospective study was performed (Korean Radiation Oncology Group [KROG] 11-06) on a total of 1,445 patients from 15 institutions.

Results: Of the 1,445 patients, more than half were stages III (39.9%) and IV (35.8%). In addition to patterns of care, we also investigated trends over time with the periods 1988-1993, 1994-2002, and 2003-2011. The frequencies of magnetic resonance imaging and positron emission tomography-computed tomography were markedly increased in the third period compared to previous 2 periods. Concurrent chemoradiation (CCRT) was performed on 894 patients (61.9%), neoadjuvant chemotherapy on 468 patients (32.4%), and adjuvant chemotherapy on 366 patients (25.3%). Of stage II-IV patients, CCRT performed on 78.8% in 2003-2011 compared to 15.0% in 1988-1993. For patients treated with CCRT, cisplatin was the most commonly used agent in 81.3% of patients. Over the periods of time, commonly used radiotherapy (RT) techniques were changed from 2-dimensional RT (1988-1993, 92.5%) to 3-dimensional RT (2003-2011, 35.5%) or intensity-modulated RT (IMRT; 2003-2011, 56.5%). Median RT doses given to primary tumors, high-risk lymphatics, and low-risk lymphatics were 70.0 Gy, 58.1 Gy, and 48.0 Gy, respectively. Adoption of IMRT increased the dose per fraction and escalated total radiation dose.

Conclusion: Assessment of the patterns of care for NPC patients in South Korea demonstrated that management for NPC including diagnostic imaging, treatment regimen, RT techniques and dose schedule, advanced in accordance with the international guidelines.
KEYWORD
Nasopharyngeal neoplasms, Patterns of care, Radiotherapy, Korea
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